Dimethylformamide → HCID 9931826, compound

HRID 852153Notes

Reaction equation

HRID 852153 reaction equation
[F:1][C:2]1[CH:21]=[CH:20][C:5]2[C:6]([C:9]3[CH:14]=[CH:13][C:12]([O:15][CH2:16][C@H:17]4[CH2:19][O:18]4)=[CH:11][CH:10]=3)=[N:7][O:8][C:4]=2[CH:3]=1.C[N:23]([CH3:26])C=O>NC1C2C(=CC=CC=2)CC1.C(O)C>[F:1][C:2]1[CH:21]=[CH:20][C:5]2[C:6]([C:9]3[CH:14]=[CH:13][C:12]([O:15][CH2:16][C@H:17]([OH:18])[CH2:19][NH:23][CH:26]4[C:20]5[C:5](=[CH:4][CH:3]=[CH:2][CH:21]=5)[CH2:6][CH2:9]4)=[CH:11][CH:10]=3)=[N:7][O:8][C:4]=2[CH:3]=1

Participants

5

Reactant 2

HCID 6228DimethylformamideHCID 58928269(R)-6-fluoro-3-(4-oxiranylmethoxy-phenyl)-benzo[d]isoxazole

Product 1

HCID 9931826HCID 9931826, compound

Reagents, catalysts & solvents 2

HCID 702EthanolSolventHCID 123445(+-)-1-AminoindanSolvent

Procedure

The title compound is prepared from a mixture of (R)-6-fluoro-3-(4-oxiranylmethoxy-phenyl)-benzo[d]isoxazole in dimethylformamide and 1-aminoindan in ethanol, essentially as described above in Example 70. Purity by LC/MS=94%, [M+H]+=419.

Sources & evidence

ORD record
ord-bed3660693774bc4840983223b912a6c
Source dataset
uspto-grants-2007_08
Patent number
US07253165B2

Reaction notes

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