Dimethylformamide → HCID 9909481, compound

HRID 852159Notes

Reaction equation

HRID 852159 reaction equation
[F:1][C:2]1[CH:21]=[CH:20][C:5]2[C:6]([C:9]3[CH:14]=[CH:13][C:12]([O:15][CH2:16][C@H:17]4[CH2:19][O:18]4)=[CH:11][CH:10]=3)=[N:7][O:8][C:4]=2[CH:3]=1.C[N:23]([CH3:26])C=O>FC1C=C(C=CC=1)CN.C(O)C>[F:1][C:2]1[CH:21]=[CH:20][C:5]2[C:6]([C:9]3[CH:10]=[CH:11][C:12]([O:15][CH2:16][C@H:17]([OH:18])[CH2:19][NH:23][CH2:26][C:4]4[CH:5]=[CH:20][CH:21]=[C:2]([F:1])[CH:3]=4)=[CH:13][CH:14]=3)=[N:7][O:8][C:4]=2[CH:3]=1

Participants

5

Reactant 2

HCID 6228DimethylformamideHCID 58928269(R)-6-fluoro-3-(4-oxiranylmethoxy-phenyl)-benzo[d]isoxazole

Product 1

HCID 9909481HCID 9909481, compound

Reagents, catalysts & solvents 2

HCID 702EthanolSolventHCID 668533-FluorobenzylamineSolvent

Procedure

The title compound is prepared from a mixture of (R)-6-fluoro-3-(4-oxiranylmethoxy-phenyl)-benzo[d]isoxazole in dimethylformamide and 3-fluorobenzylamine in ethanol, essentially as described above in Example 70. Purity by LC/MS=100%, [M+H]+=411.

Sources & evidence

ORD record
ord-608885ff4f2b4db09d49deb982c6f9ad
Source dataset
uspto-grants-2007_08
Patent number
US07253165B2

Reaction notes

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