(R)-6-fluoro-3-(4-oxiranylmethoxy-phenyl)-benzo[d]isoxazole → HCID 9866249, compound

HRID 852161Notes

Reaction equation

HRID 852161 reaction equation
[F:1][C:2]1[CH:21]=[CH:20][C:5]2[C:6]([C:9]3[CH:14]=[CH:13][C:12]([O:15][CH2:16][C@H:17]4[CH2:19][O:18]4)=[CH:11][CH:10]=3)=[N:7][O:8][C:4]=2[CH:3]=1>CN(C)C=O.FC1C=CC(CN)=CC=1.C(O)C>[F:1][C:2]1[CH:21]=[CH:20][C:5]2[C:6]([C:9]3[CH:10]=[CH:11][C:12]([O:15][CH2:16][C@H:17]([OH:18])[CH2:19][NH:7][CH2:6][C:5]4[CH:20]=[CH:21][C:2]([F:1])=[CH:3][CH:4]=4)=[CH:13][CH:14]=3)=[N:7][O:8][C:4]=2[CH:3]=1

Participants

5

Reactant 1

HCID 58928269(R)-6-fluoro-3-(4-oxiranylmethoxy-phenyl)-benzo[d]isoxazole

Product 1

HCID 9866249HCID 9866249, compound

Reagents, catalysts & solvents 3

HCID 702EthanolSolventHCID 6228DimethylformamideSolventHCID 673264-FluorobenzylamineSolvent

Procedure

The title compound is prepared from a mixture of (R)-6-fluoro-3-(4-oxiranylmethoxy-phenyl)-benzo[d]isoxazole in dimethylformamide and 4-fluorobenzylamine in ethanol, essentially as described above in Example 70. Purity by LC/MS=100%, [M+H]+=411.

Sources & evidence

ORD record
ord-09a04a72da3d41868110c66b7b9a57eb
Source dataset
uspto-grants-2007_08
Patent number
US07253165B2

Reaction notes

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