4-(4-Chlorophenyl)-4-hydroxypiperidine → HCID 58928294, compound

HRID 852171Notes

Reaction equation

HRID 852171 reaction equation
[F:1][C:2]1[CH:21]=[CH:20][C:5]2[C:6]([C:9]3[CH:14]=[CH:13][C:12]([O:15][CH2:16][C@H:17]4[CH2:19][O:18]4)=[CH:11][CH:10]=3)=[N:7][O:8][C:4]=2[CH:3]=1.[Cl:22][C:23]1[CH:28]=[CH:27][C:26]([C:29]2([OH:35])[CH2:34][CH2:33][NH:32][CH2:31][CH2:30]2)=[CH:25][CH:24]=1>CN(C)C=O.C(O)C>[Cl:22][C:23]1[CH:28]=[CH:27][C:26]([C:29]2([OH:35])[CH2:30][CH2:31][N:32]([CH2:19][C@@H:17]([OH:18])[CH2:16][O:15][C:12]3[CH:11]=[CH:10][C:9]([C:6]4[C:5]5[CH:20]=[CH:21][C:2]([F:1])=[CH:3][C:4]=5[O:8][N:7]=4)=[CH:14][CH:13]=3)[CH2:33][CH2:34]2)=[CH:25][CH:24]=1

Participants

5

Reactant 2

HCID 382824-(4-Chlorophenyl)-4-hydroxypiperidineHCID 58928269(R)-6-fluoro-3-(4-oxiranylmethoxy-phenyl)-benzo[d]isoxazole

Product 1

HCID 58928294HCID 58928294, compound

Reagents, catalysts & solvents 2

HCID 702EthanolSolventHCID 6228DimethylformamideSolvent

Procedure

The title compound is prepared from a mixture of (R)-6-fluoro-3-(4-oxiranylmethoxy-phenyl)-benzo[d]isoxazole in dimethylformamide and 4-(4-chlorophenyl)-4-hydroxypiperidine in ethanol, essentially as described above in Example 70. Purity by LC/MS=100%, [M+H]+=497.

Sources & evidence

ORD record
ord-f2682e9dc827485898584cd6bafa2e14
Source dataset
uspto-grants-2007_08
Patent number
US07253165B2

Reaction notes

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