Acetonitrile → HCID 9953330, compound

HRID 852200Notes

Reaction equation

Br[CH2:2][CH2:3][CH2:4][O:5][C:6]1[CH:11]=[CH:10][C:9]([C:12]2[C:13]3[CH:20]=[CH:19][CH:18]=[CH:17][C:14]=3[S:15][CH:16]=2)=[CH:8][CH:7]=1.[F:21][C:22]1C=[C:28]([F:30])[CH:27]=[CH:26][C:23]=1CN.C(=O)([O-])[O-].[K+].[K+].[C:37](#[N:39])[CH3:38]>>[S:15]1[CH:16]=[C:12]([C:9]2[CH:10]=[CH:11][C:6]([O:5][CH2:4][CH2:3][CH2:2][NH:39][CH2:37][C:38]3[C:22]([F:21])=[CH:23][CH:26]=[CH:27][C:28]=3[F:30])=[CH:7][CH:8]=2)[C:13]2[CH:20]=[CH:19][CH:18]=[CH:17][C:14]1=2

Participants

Reactant 4

HCID 6342Acetonitrile

HCID 11430Potassium Carbonate

HCID 27332442,4-Difluorobenzylamine

HCID 179063143-[4-(3-Bromo-propoxy)-phenyl]-benzo[b]thiophene

Product 1

HCID 9953330HCID 9953330, compound

Procedure

The title compound is prepared from 3-[4-(3-bromo-propoxy)-phenyl]-benzo[b]thiophene, 2,4-difluorobenzylamine, potassium carbonate and acetonitrile essentially as described above in Example 118. Purity by LC/MS=98%, [M+H]+=410.

Sources & evidence

ORD record: ord-23cfc0a7cc19433988a55f690f44d525
Source dataset: uspto-grants-2007_08
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07253165B2

Reaction notes

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