Methanol → HCID 9887191, compound

HRID 852203Notes

Reaction equation

HRID 852203 reaction equation
Br[CH2:2][CH2:3][CH2:4][O:5][C:6]1[CH:11]=[CH:10][C:9]([C:12]2[C:13]3[CH:20]=[CH:19][CH:18]=[CH:17][C:14]=3[S:15][CH:16]=2)=[CH:8][CH:7]=1.C(=O)([O-])[O-].[K+].[NH2:26][CH:27]1[C:35]2[C:30](=[CH:31][CH:32]=[CH:33][CH:34]=2)[CH2:29][CH2:28]1.[K+].C(#N)C.CO>C(OCC)(=O)C>[S:15]1[CH:16]=[C:12]([C:9]2[CH:10]=[CH:11][C:6]([O:5][CH2:4][CH2:3][CH2:2][NH:26][CH:27]3[C:35]4[C:30](=[CH:31][CH:32]=[CH:33][CH:34]=4)[CH2:29][CH2:28]3)=[CH:7][CH:8]=2)[C:13]2[CH:20]=[CH:19][CH:18]=[CH:17][C:14]1=2

Participants

6

Reactant 4

HCID 887MethanolHCID 6342AcetonitrileHCID 179063143-[4-(3-Bromo-propoxy)-phenyl]-benzo[b]thiopheneHCID 69418970HCID 69418970, compound

Product 1

HCID 9887191HCID 9887191, compound

Reagents, catalysts & solvents 1

HCID 8857Ethyl AcetateSolvent2×

Procedure

The title compound is prepared from 3-[4-(3-bromo-propoxy)-phenyl]-benzo[b]thiophene, 1-aminoindan potassium carbonate and acetonitrile essentially as described above in Example 118 except that the column chromatography is performed with a graded solvent mixture from 100% ethyl acetate to 10% methanol in ethyl acetate. Purity by LC/MS=100%, [M+H]+=400.

Sources & evidence

ORD record
ord-f5ace8d4f1e5431a8b8f376ff69cc233
Source dataset
uspto-grants-2007_08
Patent number
US07253165B2

Reaction notes

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