Potassium Carbonate → HCID 58928268, compound

HRID 852205Notes

Reaction equation

HRID 852205 reaction equation
Br[CH2:2][CH2:3][CH2:4][O:5][C:6]1[CH:11]=[CH:10][C:9]([C:12]2[C:13]3[CH:20]=[CH:19][CH:18]=[CH:17][C:14]=3[S:15][CH:16]=2)=[CH:8][CH:7]=1.[N:21]1[CH:26]=[CH:25][CH:24]=[N:23][C:22]=1[N:27]1[CH2:32][CH2:31][NH:30][CH2:29][CH2:28]1.C(=O)([O-])[O-].[K+].[K+]>C(#N)C>[S:15]1[CH:16]=[C:12]([C:9]2[CH:10]=[CH:11][C:6]([O:5][CH2:4][CH2:3][CH2:2][N:30]3[CH2:31][CH2:32][N:27]([C:22]4[N:21]=[CH:26][CH:25]=[CH:24][N:23]=4)[CH2:28][CH2:29]3)=[CH:7][CH:8]=2)[C:13]2[CH:20]=[CH:19][CH:18]=[CH:17][C:14]1=2

Participants

5

Reactant 3

HCID 11430Potassium CarbonateHCID 887471-(2-Pyrimidinyl)piperazineHCID 179063143-[4-(3-Bromo-propoxy)-phenyl]-benzo[b]thiophene

Product 1

HCID 58928268HCID 58928268, compound

Reagents, catalysts & solvents 1

HCID 6342AcetonitrileSolvent

Procedure

The title compound is prepared from 3-[4-(3-bromo-propoxy)-phenyl]-benzo[b]thiophene, 1-(2-pyrimidyl)piperazine, potassium carbonate and acetonitrile essentially as described above in Example 118. Purity by LC/MS=99%, [M+H]+=431.

Sources & evidence

ORD record
ord-c067c9d1a31f409e9e5f20187efa2b34
Source dataset
uspto-grants-2007_08
Patent number
US07253165B2

Reaction notes

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