(R)-3-(3-oxiranylmethoxy-phenyl)-isoxazolo[5,4-b]pyridine → HCID 9864410, compound

HRID 852209Notes

Reaction equation

HRID 852209 reaction equation
[O:1]1[CH2:3][C@@H:2]1[CH2:4][O:5][C:6]1[CH:7]=[C:8]([C:12]2[C:20]3[C:15](=[N:16][CH:17]=[CH:18][CH:19]=3)[O:14][N:13]=2)[CH:9]=[CH:10][CH:11]=1>CN(C)C=O.C(O)C.C(N)C1C=CC=CC=1>[CH2:12]([NH:13][CH2:3][C@@H:2]([OH:1])[CH2:4][O:5][C:6]1[CH:11]=[CH:10][CH:9]=[C:8]([C:12]2[C:20]3[C:15](=[N:16][CH:17]=[CH:18][CH:19]=3)[O:14][N:13]=2)[CH:7]=1)[C:8]1[CH:9]=[CH:10][CH:11]=[CH:6][CH:7]=1

Participants

5

Reactant 1

HCID 58928270(R)-3-(3-oxiranylmethoxy-phenyl)-isoxazolo[5,4-b]pyridine

Product 1

HCID 9864410HCID 9864410, compound

Reagents, catalysts & solvents 3

HCID 702EthanolSolvent2×HCID 6228DimethylformamideSolventHCID 7504BenzylamineSolvent2×

Procedure

The title compound is prepared from a mixture of (R)-3-(3-oxiranylmethoxy-phenyl)-isoxazolo[5,4-b]pyridine in dimethylformamide and ethanol and benzylamine in ethanol essentially as described above in Example 102, except that 1.5 equivalents of benzylamine is used.

Sources & evidence

ORD record
ord-ebb90f346656490981d3dd64e7d24b9c
Source dataset
uspto-grants-2007_08
Patent number
US07253165B2

Reaction notes

Loading…