p-Fluoronitrobenzene → Nitrobenzene

HRID 852259Notes

Reaction equation

HRID 852259 reaction equation
[N+:1]([C:4]1[CH:9]=[CH:8][C:7](F)=[CH:6][CH:5]=1)([O-:3])=[O:2].C(COC1C=CC=CC=1O)(O)=O.[O-]CCCC.[K+]>CC(N(C)C)=O>[N+:1]([C:4]1[CH:9]=[CH:8][CH:7]=[CH:6][CH:5]=1)([O-:3])=[O:2]

Participants

5

Reactant 3

HCID 9590p-FluoronitrobenzeneHCID 22783(o-Hydroxyphenoxy)acetic acidHCID 23699084Potassium butoxide

Product 1

HCID 7416Nitrobenzene

Reagents, catalysts & solvents 1

HCID 31374DimethylacetamideSolvent

Procedure

4-nitro-fluorobenzene and 2-(carboxymethoxy)phenol were reacted together in DMA in the presence of potassium butoxide for 2 hours at 150° C. to yield 4-(2-carboxymethoxy)-phenoxy)nitrobenzene.

Sources & evidence

ORD record
ord-13d8f3553cf64dcdbb9cdc53e460f198
Source dataset
uspto-grants-2007_08
Patent number
US07253184B2

Reaction notes

Loading…