3,4-Difluorobenzylamine → HCID 20729568, compound

HRID 852299Notes

Reaction equation

HRID 852299 reaction equation
ClC(Cl)(Cl)[C:3]([C:5]1[NH:9][CH:8]=[C:7]([C:10](=[O:13])[CH2:11][CH3:12])[CH:6]=1)=[O:4].[F:16][C:17]1[CH:18]=[C:19]([CH:22]=[CH:23][C:24]=1[F:25])[CH2:20][NH2:21]>CN(C=O)C>[F:16][C:17]1[CH:18]=[C:19]([CH:22]=[CH:23][C:24]=1[F:25])[CH2:20][NH:21][C:3]([C:5]1[NH:9][CH:8]=[C:7]([C:10](=[O:13])[CH2:11][CH3:12])[CH:6]=1)=[O:4]

Participants

4

Reactant 2

HCID 1235723,4-DifluorobenzylamineHCID 27685511-[5-(Trichloroacetyl)-1H-pyrrol-3-yl]propan-1-one

Product 1

HCID 20729568HCID 20729568, compound

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

To a solution of compound 3 (1 equivalent) in DMF, at ambient temperature, was added 3,4-difluorobenzyl amine (1.2 equivalents). After 24 hours, the solvent was evaporated and the crude product 6 was used without purification.

Workup

  1. customthe solvent was evaporated
  2. customthe crude product 6 was used without purification

Sources & evidence

ORD record
ord-d54391ebdda94ecab4cbd83decac60c0
Source dataset
uspto-grants-2007_08
Patent number
US07253187B2

Reaction notes

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