反应详情

温度

52.5 °C

130 g (179 mmol) of the compound from Example 67A are dissolved in 650 ml of ethanol, 193 ml (2.68 mol) of a 40% strength aqueous methanamine solution are added and the mixture is heated at 50-55° C. for one hour. After cooling to room temperature, water and dichloromethane are added, the phases are separated and the organic phase is dried over sodium sulphate. After filtration, the mixture is evaporated to dryness under reduced pressure. The residue (117 g, 89% of theory) is reacted further without further purification.

1. temperatureAfter cooling to room temperature
2. customthe phases are separated
3. dry with materialthe organic phase is dried over sodium sulphate
4. filtrationAfter filtration
5. customthe mixture is evaporated to dryness under reduced pressure
6. customThe residue (117 g, 89% of theory) is reacted further without further purification