Acetic Anhydride → 2-(4-Fluorophenyl)-1-(2-acetamido-4-pyridyl)ethanone

Participants

Reaction Steps

12.0 g of the compound (28) are suspended in 100 ml of acetic anhydride, a spatula tip of 4-dimethylaminopyridine is added and the reaction mixture is heated under reflux for 5 h. Most of the excess acetic anhydride is distilled off, the residue is hydrolyzed and the mixture is adjusted to pH 7 using conc. ammonia. The resulting clear precipitate (29) is filtered off and dried under reduced pressure over P2O5.

Provenance & Evidence