反应详情

12.0 g of the compound (28) are suspended in 100 ml of acetic anhydride, a spatula tip of 4-dimethylaminopyridine is added and the reaction mixture is heated under reflux for 5 h. Most of the excess acetic anhydride is distilled off, the residue is hydrolyzed and the mixture is adjusted to pH 7 using conc. ammonia. The resulting clear precipitate (29) is filtered off and dried under reduced pressure over P2O5.

1. temperaturethe reaction mixture is heated
2. temperatureunder reflux for 5 h
3. distillationMost of the excess acetic anhydride is distilled off
4. filtrationThe resulting clear precipitate (29) is filtered off
5. dry with materialdried under reduced pressure over P2O5