2-Pyridinecarboxaldehyde → 3-(5-pyridin-2-yl-2H-tetrazol-2-yl)benzonitrile

HRID 852315Notes

Reaction equation

HRID 852315 reaction equation
Cl[C:2]1[CH:3]=[C:4]([N:8]2[N:12]=[N:11][C:10]([C:13]3[CH:18]=[CH:17][CH:16]=[CH:15][N:14]=3)=[N:9]2)[CH:5]=[CH:6][CH:7]=1.[NH2:19][C:20]1C=C(C=CC=1)C#N.C1C=C(C=O)N=CC=1>>[N:14]1[CH:15]=[CH:16][CH:17]=[CH:18][C:13]=1[C:10]1[N:11]=[N:12][N:8]([C:4]2[CH:3]=[C:2]([CH:7]=[CH:6][CH:5]=2)[C:20]#[N:19])[N:9]=1

Participants

4

Reactant 3

HCID 142732-PyridinecarboxaldehydeHCID 167023-AminobenzonitrileHCID 99213692-[2-(3-chlorophenyl)-2H-tetrazol-5-yl]pyridine

Product 1

HCID 101988113-(5-pyridin-2-yl-2H-tetrazol-2-yl)benzonitrile

Procedure

By following the procedure described in EXAMPLE 1 for the synthesis of 2-[2-(3-chlorophenyl)-2H-tetrazol-5-yl]pyridine, except that 3-amino benzonitrile (709 mg, 6.0 mmol) and 2-pyridyl carboxaldehyde (642 mg, 6.0 mmol) were employed, 3-(5-pyridin-2-yl-2H-tetrazol-2-yl)benzonitrile was obtained as an orange solid.

Sources & evidence

ORD record
ord-07e431e7d9d84374889b27d0d9854853
Source dataset
uspto-grants-2007_08
Patent number
US07253190B2

Reaction notes

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