3-Methoxyaniline → 2-[2-(3-methoxyphenyl)-2H-tetrazol-5-yl]pyridine

HRID 852322Notes

Reaction equation

HRID 852322 reaction equation
Cl[C:2]1[CH:3]=[C:4]([N:8]2[N:12]=[N:11][C:10]([C:13]3[CH:18]=[CH:17][CH:16]=[CH:15][N:14]=3)=[N:9]2)[CH:5]=[CH:6][CH:7]=1.[CH3:19][O:20]C1C=CC=C(N)C=1.N1C=CC=CC=1C=O>>[CH3:19][O:20][C:2]1[CH:3]=[C:4]([N:8]2[N:12]=[N:11][C:10]([C:13]3[CH:18]=[CH:17][CH:16]=[CH:15][N:14]=3)=[N:9]2)[CH:5]=[CH:6][CH:7]=1

Participants

4

Reactant 3

HCID 108243-MethoxyanilineHCID 142732-PyridinecarboxaldehydeHCID 99213692-[2-(3-chlorophenyl)-2H-tetrazol-5-yl]pyridine

Product 1

HCID 98137192-[2-(3-methoxyphenyl)-2H-tetrazol-5-yl]pyridine

Procedure

Following the procedure described in EXAMPLE 1 for the synthesis of 2-[2-(3-chlorophenyl)-2H-tetrazol-5-yl]pyridine, m-anisidine (135 mg, 1.1 mmol) and pyridine-2-carboxaldehyde (118 mg, 1.1 mmol) were employed to obtain 2-[2-(3-methoxyphenyl)-2H-tetrazol-5-yl]pyridine as an orange solid.

Sources & evidence

ORD record
ord-ba8f5566debc413b9a33253d41e5c24b
Source dataset
uspto-grants-2007_08
Patent number
US07253190B2

Reaction notes

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