反应详情

温度

40 °C

Chloromethyl 2-(1-(tert-butoxycarbonyl)-4-piperidyl)-ethyl carbonate (4.9 g) was added to a solution of sodium iodide (9 g) in acetone (20 ml). After stirring at 40° C. for 2.5 hours the reaction mixture was cooled to room temperature, filtered and evaporated in vacuo. The residue was taken up in dichloromethane, washed with aqueous sodium bicarbonate and sodium thiosulfate, dried over magnesium sulfate, filtered and evaporated in vacuo. Purification on silica gel with hexane/ethyl acetate (2:1) as eluent gave the title compound as a light yellow oil.

1. temperaturewas cooled to room temperature
2. filtrationfiltered
3. customevaporated in vacuo
4. washwashed with aqueous sodium bicarbonate and sodium thiosulfate
5. dry with materialdried over magnesium sulfate
6. filtrationfiltered
7. customevaporated in vacuo
8. customPurification on silica gel with hexane/ethyl acetate (2:1) as eluent