2-(4-Acetylsulfanyl-2-methyl-phenoxy)-2-methyl-propionic acid ethyl ester → 2-Methyl-2-{2-methyl-4-[5-(3-trifluoromethoxy-phenyl)-pent-4-ynylsulfanyl]-phenoxy}-propionic acid ethyl ester

HRID 852360Notes

Reaction equation

HRID 852360 reaction equation
[CH2:1]([O:3][C:4](=[O:20])[C:5]([O:8][C:9]1[CH:14]=[CH:13][C:12]([S:15][C:16](=O)[CH3:17])=[CH:11][C:10]=1[CH3:19])([CH3:7])[CH3:6])[CH3:2].[F:21][C:22]([F:41])([F:40])[O:23][C:24]1[CH:25]=[C:26]([C:30]#[C:31][CH2:32]CCOS(C)(=O)=O)[CH:27]=[CH:28][CH:29]=1>>[CH2:1]([O:3][C:4](=[O:20])[C:5]([CH3:7])([O:8][C:9]1[CH:14]=[CH:13][C:12]([S:15][CH2:16][CH2:17][CH2:32][C:31]#[C:30][C:26]2[CH:27]=[CH:28][CH:29]=[C:24]([O:23][C:22]([F:21])([F:40])[F:41])[CH:25]=2)=[CH:11][C:10]=1[CH3:19])[CH3:6])[CH3:2]

Participants

3

Reactant 2

HCID 865978202-(4-Acetylsulfanyl-2-methyl-phenoxy)-2-methyl-propionic acid ethyl esterHCID 86602537Methanesulfonic acid 5-(3-trifluoromethoxy-phenyl)-pent-4-ynyl ester

Product 1

HCID 694591602-Methyl-2-{2-methyl-4-[5-(3-trifluoromethoxy-phenyl)-pent-4-ynylsulfanyl]-phenoxy}-propionic acid ethyl ester

Procedure

In analogy to the procedure described in example 1D], 2-(4-acetylsulfanyl-2-methyl-phenoxy)-2-methyl-propionic acid ethyl ester (example 1C]) was reacted with methanesulfonic acid 5-(3-trifluoromethoxy-phenyl)-pent-4-ynyl ester (example 3D]) to give 2-methyl-2-{2-methyl-4-[5-(3-trifluoromethoxy-phenyl)-pent-4-ynylsulfanyl]-phenoxy}-propionic acid ethyl ester as light brown oil.

Sources & evidence

ORD record
ord-9ae1ea31f7ff4cbf916c92c27fb5eca5
Source dataset
uspto-grants-2007_08
Patent number
US07253192B2

Reaction notes

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