Methanesulfonic acid 5-(4-trifluoromethoxy-phenyl)-pent-4-ynyl ester → HCID 69460308, compound

HRID 852384Notes

Reaction equation

HRID 852384 reaction equation
[CH3:1][O:2][C:3](=[O:17])[C:4]([O:7][C:8]1[CH:13]=[C:12]([Cl:14])[C:11]([OH:15])=[CH:10][C:9]=1[Cl:16])([CH3:6])[CH3:5].[F:18][C:19]([F:38])([F:37])[O:20][C:21]1[CH:26]=[CH:25][C:24]([C:27]#[C:28][CH2:29][CH2:30][CH2:31]OS(C)(=O)=O)=[CH:23][CH:22]=1>C(#N)C>[CH3:1][O:2][C:3](=[O:17])[C:4]([O:7][C:8]1[CH:13]=[C:12]([Cl:14])[C:11]([O:15][CH2:31][CH2:30][CH2:29][C:28]#[C:27][C:24]2[CH:25]=[CH:26][C:21]([O:20][C:19]([F:18])([F:37])[F:38])=[CH:22][CH:23]=2)=[CH:10][C:9]=1[Cl:16])([CH3:6])[CH3:5]

Participants

4

Reactant 2

HCID 11616756Methanesulfonic acid 5-(4-trifluoromethoxy-phenyl)-pent-4-ynyl esterHCID 67402766HCID 67402766, compound

Product 1

HCID 69460308HCID 69460308, compound

Reagents, catalysts & solvents 1

HCID 6342AcetonitrileSolvent

Procedure

In analogy to the procedure described in. example 20A], 2-(2,5-dichloro-4-hydroxy-phenoxy)-2-methyl-propionic acid methyl ester was treated with methanesulfonic acid 5-(4-trifluoromethoxy-phenyl)-pent-4-ynyl ester (example 1G]) in acetonitrile at the reflux temperature of the solvent for 3 h to give the title compound as colorless oil.

Sources & evidence

ORD record
ord-9fb1bf3dc5c5434eb911069067f8fd9b
Source dataset
uspto-grants-2007_08
Patent number
US07253192B2

Reaction notes

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