1-Chloro-2-fluoro-4-iodobenzene → 2-{4-[5-(4-Chloro-3-fluoro-phenyl)-pent-4-ynyloxy]-2-methyl-phenoxy}-2-methyl-propionic acid

HRID 852393Notes

Reaction equation

HRID 852393 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][C:5](I)=[CH:4][C:3]=1[F:9].[CH3:10][C:11]([O:16][C:17]1[CH:22]=[CH:21][C:20]([O:23][CH2:24][CH2:25][CH2:26][C:27]#[CH:28])=[CH:19][C:18]=1[CH3:29])([CH3:15])[C:12]([OH:14])=[O:13]>>[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([C:28]#[C:27][CH2:26][CH2:25][CH2:24][O:23][C:20]2[CH:21]=[CH:22][C:17]([O:16][C:11]([CH3:15])([CH3:10])[C:12]([OH:14])=[O:13])=[C:18]([CH3:29])[CH:19]=2)=[CH:4][C:3]=1[F:9]

Participants

3

Reactant 2

HCID 27365631-Chloro-2-fluoro-4-iodobenzeneHCID 86602542HCID 86602542, compound

Product 1

HCID 116970882-{4-[5-(4-Chloro-3-fluoro-phenyl)-pent-4-ynyloxy]-2-methyl-phenoxy}-2-methyl-propionic acid

Procedure

In analogy to the procedure described in example 24E], 1-chloro-2-fluoro-4-iodobenzene and 2-methyl-2-(2-methyl-4-pent-4-ynyloxy-phenoxy)-propionic acid (example 26B]), followed by purification described in example 26A] yielded the title compound as off-white powder, mp. 106-107° C., dec.

Workup

  1. customfollowed by purification

Sources & evidence

ORD record
ord-534e05cb44794528b28995468a339d5a
Source dataset
uspto-grants-2007_08
Patent number
US07253192B2

Reaction notes

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