HuagongsheHuagongshe Chemistry Print Report · For research reference only
1-Chloro-2-fluoro-4-iodobenzene → 2-{4-[5-(4-Chloro-3-fluoro-phenyl)-pent-4-ynyloxy]-2-methyl-phenoxy}-2-methyl-propionic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1-Chloro-2-fluoro-4-iodobenzene | HCID 2736563 | — |
| Reactant | HCID 86602542 | HCID 86602542 | — |
| Product | 2-{4-[5-(4-Chloro-3-fluoro-phenyl)-pent-4-ynyloxy]-2-methyl-phenoxy}-2-methyl-propionic acid | HCID 11697088 | — |
Reaction Steps
In analogy to the procedure described in example 24E], 1-chloro-2-fluoro-4-iodobenzene and 2-methyl-2-(2-methyl-4-pent-4-ynyloxy-phenoxy)-propionic acid (example 26B]), followed by purification described in example 26A] yielded the title compound as off-white powder, mp. 106-107° C., dec.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07253192B2 |
| Source dataset | uspto-grants-2007_08 |
| ORD ID | ord-534e05cb44794528b28995468a339d5a |
| Source note | uspto-grants-2007_08 |