2-Methyl-2-(4-methylaminomethyl-phenoxy)-propionic acid ethyl ester → 2-Methyl-2-[4-({methyl-[5-(4-trifluoromethoxy-phenyl)-pent-4-ynoyl]-amino}-methyl)-phenoxy]-propionic acid ethyl ester

HRID 852399Notes

Reaction equation

HRID 852399 reaction equation
[CH2:1]([O:3][C:4](=[O:18])[C:5]([CH3:17])([O:7][C:8]1[CH:13]=[CH:12][C:11]([CH2:14][NH:15][CH3:16])=[CH:10][CH:9]=1)[CH3:6])[CH3:2].[F:19][C:20]([F:36])([F:35])[O:21][C:22]1[CH:27]=[CH:26][C:25]([C:28]#[C:29][CH2:30][CH2:31][C:32]([OH:34])=O)=[CH:24][CH:23]=1>>[CH2:1]([O:3][C:4](=[O:18])[C:5]([CH3:17])([O:7][C:8]1[CH:9]=[CH:10][C:11]([CH2:14][N:15]([CH3:16])[C:32](=[O:34])[CH2:31][CH2:30][C:29]#[C:28][C:25]2[CH:24]=[CH:23][C:22]([O:21][C:20]([F:19])([F:36])[F:35])=[CH:27][CH:26]=2)=[CH:12][CH:13]=1)[CH3:6])[CH3:2]

Participants

3

Reactant 2

HCID 589070282-Methyl-2-(4-methylaminomethyl-phenoxy)-propionic acid ethyl esterHCID 688226854-Pentynoic acid, 5-[4-(trifluoromethoxy)phenyl]-

Product 1

HCID 694597542-Methyl-2-[4-({methyl-[5-(4-trifluoromethoxy-phenyl)-pent-4-ynoyl]-amino}-methyl)-phenoxy]-propionic acid ethyl ester

Procedure

In analogy to the procedures described in example 29A], 2-methyl-2-(4-methylaminomethyl-phenoxy)-propionic acid ethyl ester was reacted with 5-(4-trifluoromethoxy-phenyl)-pent-4-ynoic acid (example 29D]) to give the title compound as light brown oil.

Sources & evidence

ORD record
ord-0ae3d7135c9a4b7b9df13514b711e9b5
Source dataset
uspto-grants-2007_08
Patent number
US07253192B2

Reaction notes

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