Methanesulfonic acid 5-(4-trifluoromethoxy-phenyl)-pent-4-ynyl ester → 2-{3-Fluoro-2-methyl-4-[5-(4-trifluoromethoxy-phenyl)-pent-4-ynyloxy]-phenoxy}-2-methyl-propionic acid ethyl ester

HRID 852407Notes

Reaction equation

HRID 852407 reaction equation
[CH2:1]([O:3][C:4](=[O:18])[C:5]([O:8][C:9]1[CH:14]=[CH:13][C:12]([OH:15])=[C:11]([F:16])[C:10]=1[CH3:17])([CH3:7])[CH3:6])[CH3:2].[F:19][C:20]([F:39])([F:38])[O:21][C:22]1[CH:27]=[CH:26][C:25]([C:28]#[C:29][CH2:30][CH2:31][CH2:32]OS(C)(=O)=O)=[CH:24][CH:23]=1>>[CH2:1]([O:3][C:4](=[O:18])[C:5]([O:8][C:9]1[CH:14]=[CH:13][C:12]([O:15][CH2:32][CH2:31][CH2:30][C:29]#[C:28][C:25]2[CH:26]=[CH:27][C:22]([O:21][C:20]([F:19])([F:38])[F:39])=[CH:23][CH:24]=2)=[C:11]([F:16])[C:10]=1[CH3:17])([CH3:6])[CH3:7])[CH3:2]

Participants

3

Reactant 2

HCID 11616756Methanesulfonic acid 5-(4-trifluoromethoxy-phenyl)-pent-4-ynyl esterHCID 694602422-(3-Fluoro-4-hydroxy-2-methyl-phenoxy)-2-methyl-propionic acid ethyl ester

Product 1

HCID 694578272-{3-Fluoro-2-methyl-4-[5-(4-trifluoromethoxy-phenyl)-pent-4-ynyloxy]-phenoxy}-2-methyl-propionic acid ethyl ester

Procedure

In analogy to the procedure described in example 20A], 2-(3-fluoro-4-hydroxy-2-methyl-phenoxy)-2-methyl-propionic acid ethyl ester (example 33H]) and methanesulfonic acid 5-(4-trifluoromethoxy-phenyl)-pent-4-ynyl ester (example 1G]) yielded the title compound as light yellow viscous oil.

Sources & evidence

ORD record
ord-08315c49305b4b08ae0042051ebfea64
Source dataset
uspto-grants-2007_08
Patent number
US07253192B2

Reaction notes

Loading…