Propargyl bromide → 1-Prop-2-ynyl-cyclobutanecarboxylic acid ethyl ester

HRID 852413Notes

Reaction equation

[CH:1]1([C:5]([O:7][CH2:8][CH3:9])=[O:6])[CH2:4][CH2:3][CH2:2]1.[CH2:10](Br)[C:11]#[CH:12]>>[CH2:8]([O:7][C:5]([C:1]1([CH2:12][C:11]#[CH:10])[CH2:4][CH2:3][CH2:2]1)=[O:6])[CH3:9]

Participants

Reactant 2

HCID 7842Propargyl bromide

HCID 84700Ethyl cyclobutanecarboxylate

Product 1

HCID 866025441-Prop-2-ynyl-cyclobutanecarboxylic acid ethyl ester

Procedure

In analogy to the procedure described in example 24C], reaction of ethyl cyclobutanecarboxylate and propargyl bromide gave the title compound as brown liquid.

Sources & evidence

ORD record: ord-dcdd078e651c43ffb158f55122a445f5
Source dataset: uspto-grants-2007_08
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07253192B2

Reaction notes

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