1-Iodo-4-(trifluoromethoxy)benzene → 1-[3-(4-Trifluoromethoxy-phenyl)-prop-2-ynyl]-cyclobutanecarboxylic acid ethyl ester

HRID 852414Notes

Reaction equation

HRID 852414 reaction equation
[CH2:1]([O:3][C:4]([C:6]1([CH2:10][C:11]#[CH:12])[CH2:9][CH2:8][CH2:7]1)=[O:5])[CH3:2].I[C:14]1[CH:19]=[CH:18][C:17]([O:20][C:21]([F:24])([F:23])[F:22])=[CH:16][CH:15]=1>>[CH2:1]([O:3][C:4]([C:6]1([CH2:10][C:11]#[C:12][C:14]2[CH:15]=[CH:16][C:17]([O:20][C:21]([F:22])([F:23])[F:24])=[CH:18][CH:19]=2)[CH2:9][CH2:8][CH2:7]1)=[O:5])[CH3:2]

Participants

3

Reactant 2

HCID 27772941-Iodo-4-(trifluoromethoxy)benzeneHCID 866025441-Prop-2-ynyl-cyclobutanecarboxylic acid ethyl ester

Product 1

HCID 694589361-[3-(4-Trifluoromethoxy-phenyl)-prop-2-ynyl]-cyclobutanecarboxylic acid ethyl ester

Procedure

In analogy to the procedure described in example 24E], reaction of 1-prop-2-ynyl-cyclobutanecarboxylic acid ethyl ester and 1-iodo-4-trifluoromethoxybenzene gave the title compound as yellow oil.

Sources & evidence

ORD record
ord-13c2fe204eae4d1b9807d569f14929b2
Source dataset
uspto-grants-2007_08
Patent number
US07253192B2

Reaction notes

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