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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 852414Generated: October 26, 2026

1-Iodo-4-(trifluoromethoxy)benzene → 1-[3-(4-Trifluoromethoxy-phenyl)-prop-2-ynyl]-cyclobutanecarboxylic acid ethyl ester

https://huagongshe.com/reaction/852414

Reaction equation

Participants

RoleNameHCIDCharge
Reactant1-Iodo-4-(trifluoromethoxy)benzeneHCID 2777294—
Reactant1-Prop-2-ynyl-cyclobutanecarboxylic acid ethyl esterHCID 86602544—
Product1-[3-(4-Trifluoromethoxy-phenyl)-prop-2-ynyl]-cyclobutanecarboxylic acid ethyl esterHCID 69458936—

Reaction Steps

In analogy to the procedure described in example 24E], reaction of 1-prop-2-ynyl-cyclobutanecarboxylic acid ethyl ester and 1-iodo-4-trifluoromethoxybenzene gave the title compound as yellow oil.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS07253192B2
Source datasetuspto-grants-2007_08
ORD IDord-13c2fe204eae4d1b9807d569f14929b2
Source noteuspto-grants-2007_08