反应详情

温度

90 °C

To a solution of 0.78 g (2.15 mmol) methanesulfonic acid 1-[3-(4-trifluoromethoxy-phenyl)-prop-2-ynyl]-cyclobutylmethyl ester in 30 ml 2-butanone was added 0.65 g (4.30 mmol) NaI. The mixture was heated for 9 h at 90° C. The solvent was evaporated and the residue suspended in dichloromethane, ether was added and the suspension was filtrated. Evaporation of the organic phase gave 0.74 g of the title compound as dark brown oil.

1. customThe solvent was evaporated
2. additionether was added
3. filtrationthe suspension was filtrated
4. customEvaporation of the organic phase