Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Bromine | HCID 24408 | — |
| Reactant | 1-(3-Ethylpyrazinyl)ethan-1-one | HCID 61918 | — |
| Solvent | Hydrogen Bromide | HCID 260 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | HCID 86591207 | HCID 86591207 | 122.8% |
Reaction Steps
To a solution of 6 g (40 mmol) 1-(3-Ethyl-pyrazin-2-yl)-ethanone in 21 ml HBr (33%) and 7 ml methanol was added 2 ml (40 mmol) bromine and the mixture was heated to 60° C. for 3 h. After removal of the volatiles under reduced pressure the residue was washed with diethyl ether and ethyl acetate. 6.4 g (41%) of the title compound was obtained as grey solid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US07253197B2 |
|---|
| Source dataset | uspto-grants-2007_08 |
|---|
| ORD ID | ord-ae30304151954729a70d0e9019ad9ca0 |
|---|
| Source note | uspto-grants-2007_08 |
|---|
