Bromine → HCID 86591207, compound

HRID 852434Notes

Reaction equation

HRID 852434 reaction equation
[CH2:1]([C:3]1[C:4]([C:9](=[O:11])[CH3:10])=[N:5][CH:6]=[CH:7][N:8]=1)[CH3:2].[Br:12]Br>Br.CO>[BrH:12].[BrH:12].[Br:12][CH2:10][C:9]([C:4]1[C:3]([CH2:1][CH3:2])=[N:8][CH:7]=[CH:6][N:5]=1)=[O:11]

Participants

5

Reactant 2

HCID 24408BromineHCID 619181-(3-Ethylpyrazinyl)ethan-1-one

Product 1

HCID 86591207HCID 86591207, compoundYield 122.8%

Reagents, catalysts & solvents 2

HCID 260Hydrogen BromideSolventHCID 887MethanolSolvent

Conditions

Temperature
60 °C

Procedure

To a solution of 6 g (40 mmol) 1-(3-Ethyl-pyrazin-2-yl)-ethanone in 21 ml HBr (33%) and 7 ml methanol was added 2 ml (40 mmol) bromine and the mixture was heated to 60° C. for 3 h. After removal of the volatiles under reduced pressure the residue was washed with diethyl ether and ethyl acetate. 6.4 g (41%) of the title compound was obtained as grey solid.

Workup

  1. customAfter removal of the volatiles under reduced pressure the residue
  2. washwas washed with diethyl ether and ethyl acetate

Sources & evidence

ORD record
ord-ae30304151954729a70d0e9019ad9ca0
Source dataset
uspto-grants-2007_08
Patent number
US07253197B2

Reaction notes

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