2-(3-Cyano-4-methyl-5-phenyl-5-(trifluoromethyl)furan-2(5H)-ylidene)malononitrile → HCID 86667546, compound

HRID 85247Notes

Reaction equation

HRID 85247 reaction equation
[CH2:1]([O:8][C:9]1[CH:14]=[C:13]([N:15]([CH2:20][CH2:21][CH2:22][CH3:23])[CH2:16][CH2:17][CH2:18][CH3:19])[CH:12]=[CH:11][C:10]=1[CH:24]=[CH:25][C:26]1[S:30][C:29]([CH:31]=O)=[CH:28][CH:27]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[C:33]([C:35]1[C:36](=[C:51]([C:54]#[N:55])[C:52]#[N:53])[O:37][C:38]([C:45]2[CH:50]=[CH:49][CH:48]=[CH:47][CH:46]=2)([C:41]([F:44])([F:43])[F:42])[C:39]=1[CH3:40])#[N:34]>C(O)C.O1CCCC1>[CH2:1]([O:8][C:9]1[CH:14]=[C:13]([N:15]([CH2:20][CH2:21][CH2:22][CH3:23])[CH2:16][CH2:17][CH2:18][CH3:19])[CH:12]=[CH:11][C:10]=1[CH:24]=[CH:25][C:26]1[S:30][C:29]([CH:31]=[CH:40][C:39]2[C:38]([C:45]3[CH:50]=[CH:49][CH:48]=[CH:47][CH:46]=3)([C:41]([F:44])([F:42])[F:43])[O:37][C:36](=[C:51]([C:54]#[N:55])[C:52]#[N:53])[C:35]=2[C:33]#[N:34])=[CH:28][CH:27]=1)[C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1

Participants

5

Reactant 2

HCID 116740672-(3-Cyano-4-methyl-5-phenyl-5-(trifluoromethyl)furan-2(5H)-ylidene)malononitrileHCID 866675435-[2-(2-Benzyloxy-4-dibutylaminophenyl)vinyl]thiophene-2-carboaldehyde

Product 1

HCID 86667546HCID 86667546, compoundYield 94.7%

Reagents, catalysts & solvents 2

HCID 702EthanolSolventHCID 8028TetrahydrofuranSolvent

Procedure

In 15 ml of ethanol and 5 ml of tetrahydrofuran were dissolved 730 mg (1.63 mmol) of 5-[2-(2-benzyloxy-4-dibutylaminophenyl)vinyl]thiophene-2-carboaldehyde and 573 mg (1.82 mmol) of 2-(3-cyano-4-methyl-5-phenyl-5-trifluoromethyl-2(5H)-furanylidene)propanedinitrile. The mixture was stirred at room temperature for 21 hours and further stirred with heating at 50° C. for 3 hours. The solvent was evaporated off and the residue was washed with ethanol to give 1.15 g of a dark reddish brown crystal (yield: 94.7%; mp: 196-197° C.)

Workup

  1. stirringfurther stirred
  2. temperaturewith heating at 50° C. for 3 hours
  3. customThe solvent was evaporated off
  4. washthe residue was washed with ethanol

Sources & evidence

ORD record
ord-3819200bee1b49179241795caa294efb
Source dataset
uspto-grants-2014_09
Patent number
US08846955B2

Reaction notes

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