3-Ethylamino-5-(2-oxo-pyrrolidin-1-yl)-benzoic acid → [(2R,3S)-3-({1-[3-Ethylamino-5-(2-oxo-pyrrolidin-1-yl)-phenyl]-methanoyl}-amino)-2-hydroxy-4-phenyl-butyl]-carbamic acid benzyl ester

HRID 852575Notes

Reaction equation

HRID 852575 reaction equation
Cl.[CH2:2]([O:9][C:10](=[O:24])[NH:11][CH2:12][C@@H:13]([OH:23])[C@@H:14]([NH2:22])[CH2:15][C:16]1[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=1)[C:3]1[CH:8]=[CH:7][CH:6]=[CH:5][CH:4]=1.[CH2:25]([NH:27][C:28]1[CH:29]=[C:30]([CH:34]=[C:35]([N:37]2[CH2:41][CH2:40][CH2:39][C:38]2=[O:42])[CH:36]=1)[C:31](O)=[O:32])[CH3:26]>>[CH2:2]([O:9][C:10](=[O:24])[NH:11][CH2:12][C@@H:13]([OH:23])[C@@H:14]([NH:22][C:31]([C:30]1[CH:34]=[C:35]([N:37]2[CH2:41][CH2:40][CH2:39][C:38]2=[O:42])[CH:36]=[C:28]([NH:27][CH2:25][CH3:26])[CH:29]=1)=[O:32])[CH2:15][C:16]1[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=1)[C:3]1[CH:4]=[CH:5][CH:6]=[CH:7][CH:8]=1

Participants

3

Reactant 2

HCID 693577543-Ethylamino-5-(2-oxo-pyrrolidin-1-yl)-benzoic acidHCID 69358558phenylmethyl [(2R,3S)-3-amino-2-hydroxy-4-phenylbutyl]carbamate hydrochloride

Product 1

HCID 69356635[(2R,3S)-3-({1-[3-Ethylamino-5-(2-oxo-pyrrolidin-1-yl)-phenyl]-methanoyl}-amino)-2-hydroxy-4-phenyl-butyl]-carbamic acid benzyl ester

Procedure

Description 106 was prepared in an analogous manner to Description 105 from 3-(2-oxo-pyrrolidin-1-yl)-5-pentyloxy-benzoic acid hydrochloride (D104) and 3-ethylamino-5-(2-oxo-pyrrolidin-1-yl)-benzoic acid (A31).

Sources & evidence

ORD record
ord-cb9efeb4c0d849728c9561aaae1ed092
Source dataset
uspto-grants-2007_08
Patent number
US07253198B2

Reaction notes

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