3-(2-Oxo-pyrrolidin-1-yl)-5-isopropylamino-benzoic acid hydrochloride → [(2R,3S)-3-({1-[3-Isopropylamino-5-(2-oxo-pyrrolidin-1-yl)-phenyl]-methanoyl}-amino)-2-hydroxy-4-phenyl-butyl]-carbamic acid benzyl ester

HRID 852576Notes

Reaction equation

HRID 852576 reaction equation
Cl.[O:2]=[C:3]1[CH2:7][CH2:6][CH2:5][N:4]1[C:8]1[CH:9]=[C:10]([CH:14]=[C:15]([NH:17][CH:18]([CH3:20])[CH3:19])[CH:16]=1)[C:11]([OH:13])=O.Cl.[CH2:22]([O:29][C:30](=[O:44])[NH:31][CH2:32][C@@H:33]([OH:43])[C@@H:34]([NH2:42])[CH2:35][C:36]1[CH:41]=[CH:40][CH:39]=[CH:38][CH:37]=1)[C:23]1[CH:28]=[CH:27][CH:26]=[CH:25][CH:24]=1>>[CH2:22]([O:29][C:30](=[O:44])[NH:31][CH2:32][C@@H:33]([OH:43])[C@@H:34]([NH:42][C:11]([C:10]1[CH:9]=[C:8]([N:4]2[CH2:5][CH2:6][CH2:7][C:3]2=[O:2])[CH:16]=[C:15]([NH:17][CH:18]([CH3:20])[CH3:19])[CH:14]=1)=[O:13])[CH2:35][C:36]1[CH:41]=[CH:40][CH:39]=[CH:38][CH:37]=1)[C:23]1[CH:24]=[CH:25][CH:26]=[CH:27][CH:28]=1

Participants

3

Reactant 2

HCID 693577483-(2-Oxo-pyrrolidin-1-yl)-5-isopropylamino-benzoic acid hydrochlorideHCID 69358558phenylmethyl [(2R,3S)-3-amino-2-hydroxy-4-phenylbutyl]carbamate hydrochloride

Product 1

HCID 69357723[(2R,3S)-3-({1-[3-Isopropylamino-5-(2-oxo-pyrrolidin-1-yl)-phenyl]-methanoyl}-amino)-2-hydroxy-4-phenyl-butyl]-carbamic acid benzyl ester

Procedure

Description 107 was prepared in an analogous manner to Description 105 from 3-(2-oxo-pyrrolidin-1-yl)-5-isopropylamino-benzoic acid hydrochloride (A44) and ((2R,3S)-3-amino-2-hydroxy-4-phenyl-butyl)-carbamic acid benzyl ester (D104).

Sources & evidence

ORD record
ord-f9074b248c9f4bc4a2c1e0896337a9b9
Source dataset
uspto-grants-2007_08
Patent number
US07253198B2

Reaction notes

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