Benzyl Alcohol → 1,1-Dimethylethyl {1,1-dimethyl-2-[(phenylmethyl)oxy]ethyl}carbamate

HRID 852626Notes

Reaction equation

HRID 852626 reaction equation
CS([O:5][CH2:6][C:7]([NH:10][C:11]([O:13][C:14]([CH3:17])([CH3:16])[CH3:15])=[O:12])([CH3:9])[CH3:8])(=O)=O.CC(NC(=O)OC(C)(C)C)(C)COC1C=CC=CC=1.[C:37]1([CH2:43]O)[CH:42]=[CH:41][CH:40]=[CH:39][CH:38]=1>>[CH3:8][C:7]([NH:10][C:11](=[O:12])[O:13][C:14]([CH3:17])([CH3:16])[CH3:15])([CH3:9])[CH2:6][O:5][CH2:43][C:37]1[CH:42]=[CH:41][CH:40]=[CH:39][CH:38]=1

Participants

4

Reactant 3

HCID 244Benzyl AlcoholHCID 11659022Methanesulfonic acid 2-tert-butoxycarbonylamino-2-methyl-propyl esterHCID 866028801,1-Dimethylethyl [1,1-dimethyl-2-(phenyloxy)ethyl]carbamate

Product 1

HCID 577185591,1-Dimethylethyl {1,1-dimethyl-2-[(phenylmethyl)oxy]ethyl}carbamate

Procedure

1,1-Dimethylethyl {1,1-dimethyl-2-[(phenylmethyl)oxy]ethyl}carbamate (D275) was prepared from 2-({[(1,1-dimethylethyl)oxy]carbonyl}amino)-2-methylpropyl methanesulfonate (D273) in an analogous manner to 1,1-dimethylethyl [1,1-dimethyl-2-(phenyloxy)ethyl]carbamate (D274) using phenylmethanol instead of phenol.

Sources & evidence

ORD record
ord-ce868e6eef6b4c588cfdbe61caaf4f38
Source dataset
uspto-grants-2007_08
Patent number
US07253198B2

Reaction notes

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