HRID8527

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID6422

未命名化合物

结构：CC(=O)NC(Cc1ccc(O)cc1)C(=O)NC(Cc1ccc(F)cc1)C(=O)N1CC(=O)N(CCc2ccc3ccccc3c2)CC1CCCNC(=NC(=O)OC(C)(C)C)NC(=O)OC(C)(C)C

HCID178418893

未命名化合物

PRODUCTS

生成物

结构：CC(=O)NC(Cc1ccc(O)cc1)C(=O)NC(Cc1ccc(F)cc1)C(=O)N1CC(=O)N(CCc2ccc3ccccc3c2)CC1CCCNC(=N)N

HCID178418937

未命名化合物

收率 86%

AUXILIARIES

试剂、催化剂与溶剂

溶剂HCID6344

Dichloromethane

CH2Cl2

PROCEDURE

实验过程

A solution of 2-acetylamino-N-[2-[2-[3-(N′,N″-di-Boc-guanidino)propyl]-4-(2-naphthalen-2-ylethyl)-5-oxo-piperazin-1-yl]-1-(4-fluorobenzyl)-2-oxo-ethyl]-3-(4-hydroxyphenyl)-propionamide, 36, (35 mg, 38 mmol), trifluoroacetic acid (1 mL) and dichloromethane (2 mL) is stirred at room temperature for 5 hours. The solution is concentrated in vacuo and the crude product purified over silica gel (acetonitrile:TFA:water) to afford 24 mg (86% yield) of the final product which corresponds to analog 227, Table IV.

WORKUP

后处理

concentrationThe solution is concentrated in vacuo
customthe crude product purified over silica gel (acetonitrile:TFA:water)

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-b3071ba7b71a49d8b139e5505012e8dc
来源数据集: uspto-grants-2006_08
DOI: 10.6084/m9.figshare.5104873.v1
专利: US07087759B2
来源说明: uspto-grants-2006_08

反应 SMILES

[C:1]([NH:4][CH:5]([CH2:60][C:61]1[CH:66]=[CH:65][C:64]([OH:67])=[CH:63][CH:62]=1)[C:6]([NH:8][CH:9]([CH2:52][C:53]1[CH:58]=[CH:57][C:56]([F:59])=[CH:55][CH:54]=1)[C:10]([N:12]1[CH2:17][C:16](=[O:18])[N:15]([CH2:19][CH2:20][C:21]2[CH:30]=[CH:29][C:28]3[C:23](=[CH:24][CH:25]=[CH:26][CH:27]=3)[CH:22]=2)[CH2:14][CH:13]1[CH2:31][CH2:32][CH2:33][NH:34][C:35]([NH:44]C(OC(C)(C)C)=O)=[N:36]C(OC(C)(C)C)=O)=[O:11])=[O:7])(=[O:3])[CH3:2].FC(F)(F)C(O)=O>ClCCl>[C:1]([NH:4][CH:5]([CH2:60][C:61]1[CH:62]=[CH:63][C:64]([OH:67])=[CH:65][CH:66]=1)[C:6]([NH:8][CH:9]([CH2:52][C:53]1[CH:58]=[CH:57][C:56]([F:59])=[CH:55][CH:54]=1)[C:10]([N:12]1[CH2:17][C:16](=[O:18])[N:15]([CH2:19][CH2:20][C:21]2[CH:30]=[CH:29][C:28]3[C:23](=[CH:24][CH:25]=[CH:26][CH:27]=3)[CH:22]=2)[CH2:14][CH:13]1[CH2:31][CH2:32][CH2:33][NH:34][C:35]([NH2:44])=[NH:36])=[O:11])=[O:7])(=[O:3])[CH3:2]