Cyclooctylamine → 1-Benzoyl-3-cyclooctylthiourea

HRID 852755Notes

Reaction equation

HRID 852755 reaction equation
[C:1]([N:9]=[C:10]=[S:11])(=[O:8])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[CH:12]1([NH2:20])[CH2:19][CH2:18][CH2:17][CH2:16][CH2:15][CH2:14][CH2:13]1>C(Cl)(Cl)Cl>[C:1]([NH:9][C:10]([NH:20][CH:12]1[CH2:19][CH2:18][CH2:17][CH2:16][CH2:15][CH2:14][CH2:13]1)=[S:11])(=[O:8])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

Participants

4

Reactant 2

HCID 2903CyclooctylamineHCID 68284Benzoyl isothiocyanate

Product 1

HCID 589299211-Benzoyl-3-cyclooctylthiourea

Reagents, catalysts & solvents 1

HCID 6212ChloroformSolvent

Procedure

Benzoyl isothiocyanate (7.40 mL, 54.0 mmol) was added to a solution of cyclooctanamine (6.25 g, 49.1 mmol) in 200 mL of chloroform. The mixture was stirred at ambient temperature overnight. The solvents were removed in vacuo to give the title compound as a viscous light yellowish oil. MS m/z: 291.0 (M+H)+.

Workup

  1. customThe solvents were removed in vacuo

Sources & evidence

ORD record
ord-1b6f7f8254cb4375bbd1f0c7ffdb5264
Source dataset
uspto-grants-2007_08
Patent number
US07253196B2

Reaction notes

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