(R)-5-(4-Benzyloxy-phenyl)-4-tert-butoxycarbonylamino-pent-2-enoic acid methyl ester → 4-Amino-5-(4-benzyloxy-phenyl)-pent-2-enoic acid methyl ester

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Reaction Steps

(R)-5-(4-Benzyloxy-phenyl)-4-tert-butoxycarbonylamino-pent-2-enoic acid methyl ester (3.0 g, 0.0073 mol) was added to TFA (10 ml) at 0° C. with stirring. After 10 min, ice was added, and the mixture extracted into EtOAc. The extracts were washed with K2CO3 solution (20% w/v) and brine, dried with MgSO4, and evaporated to afford 2.23 g (98%) of the title compound.

Provenance & Evidence