反应详情

(R)-5-(4-Benzyloxy-phenyl)-4-tert-butoxycarbonylamino-pent-2-enoic acid methyl ester (3.0 g, 0.0073 mol) was added to TFA (10 ml) at 0° C. with stirring. After 10 min, ice was added, and the mixture extracted into EtOAc. The extracts were washed with K2CO3 solution (20% w/v) and brine, dried with MgSO4, and evaporated to afford 2.23 g (98%) of the title compound.

1. additionice was added
2. extractionthe mixture extracted into EtOAc
3. washThe extracts were washed with K2CO3 solution (20% w/v) and brine
4. dry with materialdried with MgSO4
5. customevaporated