Diisopropylethylamine → HCID 178466182, compound

HRID 853021Notes

Reaction equation

HRID 853021 reaction equation
[CH2:1]([O:3][C:4]1[C:13]2[C:8](=[CH:9][CH:10]=[C:11]([CH:14]=[C:15]3[S:19][C:18](SC)=[N:17][C:16]3=[O:22])[CH:12]=2)[N:7]=[CH:6][CH:5]=1)[CH3:2].[CH2:23]([O:25][C:26]1[CH:31]=[CH:30][CH:29]=[CH:28][C:27]=1[CH2:32][CH2:33][NH2:34])[CH3:24].CCN(C(C)C)C(C)C>>[CH2:23]([O:25][C:26]1[CH:31]=[CH:30][CH:29]=[CH:28][C:27]=1[CH2:32][CH2:33][NH:34][C:18]1[S:19]/[C:15](=[CH:14]\[C:11]2[CH:12]=[C:13]3[C:8](=[CH:9][CH:10]=2)[N:7]=[CH:6][CH:5]=[C:4]3[O:3][CH2:1][CH3:2])/[C:16](=[O:22])[N:17]=1)[CH3:24]

Participants

4

Reactant 3

HCID 81531DiisopropylethylamineHCID 1423622-EthoxyphenethylamineHCID 694667775-(4-Ethoxy-quinolin-6-ylmethylene)-2-methylsulfanyl-thiazol-4-one

Product 1

HCID 178466182HCID 178466182, compound

Procedure

Similar procedure as described in example 40c was used, starting from 5-(4-ethoxy-quinolin-6-ylmethylene)-2-methylsulfanyl-thiazol-4-one (example 40b), 2-(2-ethoxy-phenyl)-ethylamine and DIEA to give 2-[2-(2-ethoxy-phenyl)-ethylamino]-5-[1-(4-ethoxy-quinolin-6-yl)-meth-(Z)-ylidene]-thiazol-4-one. LC-MS m/e 448 (MH+).

Sources & evidence

ORD record
ord-36a003f83f53404082936c45d98217da
Source dataset
uspto-grants-2007_08
Patent number
US07253285B2

Reaction notes

Loading…