Methanesulfonic Acid → HCID 178466914, compound

HRID 853023Notes

Reaction equation

[F:1][C:2]([F:31])([C:25]1[CH:30]=[CH:29][CH:28]=[CH:27][N:26]=1)[CH2:3][NH:4][C:5]1[S:6]/[C:7](=[CH:11]\[C:12]2[CH:13]=[C:14]3[C:19](=[CH:20][CH:21]=2)[N:18]=[CH:17][CH:16]=[C:15]3[O:22][CH2:23][CH3:24])/[C:8](=[O:10])[N:9]=1.[CH3:32][S:33]([OH:36])(=[O:35])=[O:34]>>[CH3:32][S:33]([OH:36])(=[O:35])=[O:34].[F:31][C:2]([F:1])([C:25]1[CH:30]=[CH:29][CH:28]=[CH:27][N:26]=1)[CH2:3][NH:4][C:5]1[S:6]/[C:7](=[CH:11]\[C:12]2[CH:13]=[C:14]3[C:19](=[CH:20][CH:21]=2)[N:18]=[CH:17][CH:16]=[C:15]3[O:22][CH2:23][CH3:24])/[C:8](=[O:10])[N:9]=1

Participants

Reactant 2

HCID 6395Methanesulfonic Acid

HCID 178466913HCID 178466913, compound

Product 1

HCID 178466914HCID 178466914, compound

Procedure

Similar procedure as described in example 42 was used, starting from 2-(2,2-difluoro-2-pyridin-2-yl-ethylamino)-5-[1-(4-ethoxy-quinolin-6-yl)-meth-(Z)-ylidene]-thiazol-4-one (example 43) and methanesulfonic acid to give 2-(2,2-difluoro-2-pyridin-2-yl-ethylamino)-5-[1-(4-ethoxy-quinolin-6-yl)-meth-(Z)-ylidene]-thiazol-4-one; compound with methanesulfonic acid. LC-MS m/e 441 (MH+).

Sources & evidence

ORD record: ord-7b8724b3f9ea4bddab4f531315320b6b
Source dataset: uspto-grants-2007_08
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07253285B2

Reaction notes

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