HuagongsheHuagongshe Chemistry Print Report · For research reference only
Potassium Carbonate → 2-[4-(3-fluoro-benzyloxy)-phenoxy]-N-methyl-acetamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | 3-Fluorobenzyl bromide | HCID 68007 | — |
| Reactant | 2-(4-hydroxyphenoxy)-N-methylacetamide | HCID 18183913 | — |
| Solvent | Methyl Ethyl Ketone | HCID 6569 | — |
| Product | 2-[4-(3-fluoro-benzyloxy)-phenoxy]-N-methyl-acetamide | HCID 11601710 | — |
Reaction Steps
In analogy to the procedure described in Example 3b), the alkylation of 2-(4-hydroxy-phenoxy)-N-methyl-acetamide [Example 3a)] with 1-bromomethyl-3-fluoro-benzene in 2-butanone using potassium carbonate as the base yielded the 2-[4-(3-fluoro-benzyloxy)-phenoxy]-N-methyl-acetamide as white crystals; MS: m/e=290 (M+H)+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07253318B2 |
| Source dataset | uspto-grants-2007_08 |
| ORD ID | ord-656c9ed81cd04eacb669f984c8775aaa |
| Source note | uspto-grants-2007_08 |