Methylamine → HCID 11551014, compound

Participants

Reaction Conditions

Reaction Steps

A mixture of 500 mg of [4(4-fluoro-benzyloxy)-phenoxy]-acetic acid ethyl ester [Example 1b)] and 2 ml of methylamine (about 8 M in ethanol) was stirred at 80° C. during 18 h. For the working-up, the solution was cooled to room temperature and treated with water. The pure product precipitated and was collected on a filter funnel. After drying there were obtained 398 mg (86% of theory) of 2-[4-(4-fluoro-benzyloxy)-phenoxy]-N-methyl-acetamide as white crystals; MS: m/e=290 (M+H)+.

Provenance & Evidence