Methylamine → HCID 11551014, compound

HRID 853153Notes

Reaction equation

HRID 853153 reaction equation
C([O:3][C:4](=O)[CH2:5][O:6][C:7]1[CH:12]=[CH:11][C:10]([O:13][CH2:14][C:15]2[CH:20]=[CH:19][C:18]([F:21])=[CH:17][CH:16]=2)=[CH:9][CH:8]=1)C.[CH3:23][NH2:24]>O>[F:21][C:18]1[CH:19]=[CH:20][C:15]([CH2:14][O:13][C:10]2[CH:11]=[CH:12][C:7]([O:6][CH2:5][C:4]([NH:24][CH3:23])=[O:3])=[CH:8][CH:9]=2)=[CH:16][CH:17]=1

Participants

4

Reactant 2

HCID 6329MethylamineHCID 69037550HCID 69037550, compound

Product 1

HCID 11551014HCID 11551014, compoundYield 86%

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Conditions

Temperature
80 °C

Procedure

A mixture of 500 mg of [4(4-fluoro-benzyloxy)-phenoxy]-acetic acid ethyl ester [Example 1b)] and 2 ml of methylamine (about 8 M in ethanol) was stirred at 80° C. during 18 h. For the working-up, the solution was cooled to room temperature and treated with water. The pure product precipitated and was collected on a filter funnel. After drying there were obtained 398 mg (86% of theory) of 2-[4-(4-fluoro-benzyloxy)-phenoxy]-N-methyl-acetamide as white crystals; MS: m/e=290 (M+H)+.

Workup

  1. temperaturethe solution was cooled to room temperature
  2. customThe pure product precipitated
  3. customwas collected on a filter funnel
  4. customAfter drying there

Sources & evidence

ORD record
ord-5d384f9476ee449bba557024160f7088
Source dataset
uspto-grants-2007_08
Patent number
US07253318B2

Reaction notes

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