Trifluoroacetic acid → HCID 69039797, compound

HRID 853170Notes

Reaction equation

HRID 853170 reaction equation
[F:1][C:2]1[CH:3]=[C:4]([CH:15]=[CH:16][CH:17]=1)[CH2:5][O:6][C:7]1[CH:12]=[CH:11][C:10]([CH2:13][OH:14])=[CH:9][CH:8]=1.[N-:18]=[C:19]=[O:20].[K+].FC(F)(F)C(O)=O>C1C=CC=CC=1>[F:1][C:2]1[CH:3]=[C:4]([CH:15]=[CH:16][CH:17]=1)[CH2:5][O:6][C:7]1[CH:12]=[CH:11][C:10]([CH2:13][O:14][C:19](=[O:20])[NH2:18])=[CH:9][CH:8]=1

Participants

5

Reactant 3

HCID 6422Trifluoroacetic acidHCID 887902Safinamide Impurity 8HCID 11051572Potassio isocyanate

Product 1

HCID 69039797HCID 69039797, compound

Reagents, catalysts & solvents 1

HCID 241BenzeneSolvent

Procedure

In analogy to the procedure described in Example 24 b), the reaction of [4-(3-fluoro-benzyloxy)-phenyl]-methanol with potassium isocyanate and trifluoroacetic acid in benzene yielded the carbamic acid 4-(3-fluoro-benzyloxy)-benzyl ester as a white solid; MS: m/e=293 (M+NH4)+.

Sources & evidence

ORD record
ord-65ecf41e23cb414b856d00a353fc0b2e
Source dataset
uspto-grants-2007_08
Patent number
US07253318B2

Reaction notes

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