Ethyl Acetate → HCID 22936271, compound

HRID 853255Notes

Reaction equation

HRID 853255 reaction equation
[C:1]1([C:7]2[CH:12]=[C:11]([O:13][C:14]3[CH:20]=[CH:19][C:17]([NH2:18])=[CH:16][CH:15]=3)[CH:10]=[CH:9][N:8]=2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.C(OCC)(=O)C.[F:27][C:28]1[CH:33]=[CH:32][C:31]([N:34]=[C:35]=[O:36])=[CH:30][CH:29]=1>CCCCCC>[C:1]1([C:7]2[CH:12]=[C:11]([O:13][C:14]3[CH:15]=[CH:16][C:17]([NH:18][C:35]([NH:34][C:31]4[CH:32]=[CH:33][C:28]([F:27])=[CH:29][CH:30]=4)=[O:36])=[CH:19][CH:20]=3)[CH:10]=[CH:9][N:8]=2)[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=1

Participants

5

Reactant 3

HCID 8857Ethyl AcetateHCID 709554-Fluorophenyl isocyanateHCID 22936711HCID 22936711, compound

Product 1

HCID 22936271HCID 22936271, compound

Reagents, catalysts & solvents 1

HCID 8058HexaneSolvent

Procedure

4-(2-Phenylpyridin-4-yl)oxyaniline (110 mg, 0.42 mM) was added to ethyl acetate (10 ml), and then parafluorophenyl isocyanate (0.56 ml, 4.9 mM) was added while stirring, which was continued for 30 minutes. After adding n-hexane (20 ml) to the reaction solution, the solvent was partially distilled off under reduced pressure and the precipitating solid was filtered out to obtain the target substance (98 mg) as a gray solid.

Workup

  1. distillationthe solvent was partially distilled off under reduced pressure
  2. filtrationthe precipitating solid was filtered out
  3. customto obtain the target substance (98 mg) as a gray solid

Sources & evidence

ORD record
ord-8de2fcc2e88b4f67a1981bb1c8fd0c24
Source dataset
uspto-grants-2007_08
Patent number
US07253286B2

Reaction notes

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