反应详情

The 4-(4-aminophenoxy)-6-cyano-7-(2-methoxyethoxy)quinoline (100 mg) synthesized in Production Example 10 and phenyl N-(5-methylisoxazol-3-yl)carbamate (72 mg) were added to toluene (5 ml), and then diisopropylethylamine (0.50 ml) was added and the mixture was heated to reflux for 2 hours. After cooling, the precipitated crystals were filtered and washed with an ethyl acetate/toluene (1/1) mixed solvent to obtain the title compound (120 mg).

1. temperaturethe mixture was heated
2. temperatureto reflux for 2 hours
3. temperatureAfter cooling
4. filtrationthe precipitated crystals were filtered
5. washwashed with an ethyl acetate/toluene (1/1)
6. additionmixed solvent