反应详情

温度

140 °C

After adding 84 ml of formic acid, 338 ml of formamide and 169 ml of dimethylformamide to 56.7 g of the ethyl 2-amino-5-(4-benzyloxyphenyl)-1H-pyrrole-3-carboxylate synthesized in Production Example 153-1, the mixture was stirred at 140° C. for 48 hours and then allowed to stand at room temperature for 24 hours. The precipitated solid was filtered out and dried under reduced pressure to obtain 41 g of the title compound.

1. customsynthesized in Production Example 153-1
2. waitto stand at room temperature for 24 hours
3. filtrationThe precipitated solid was filtered out
4. customdried under reduced pressure