HCID 22936266, compound → HCID 22936256, compound

HRID 853468Notes

Reaction equation

HRID 853468 reaction equation
F[C:2](F)(F)[C:3](O)=[O:4].[NH2:8][CH2:9][C:10]1[CH:11]=[C:12]2[C:17](=[CH:18][C:19]=1[O:20][CH3:21])[N:16]=[CH:15][CH:14]=[C:13]2[O:22][C:23]1[CH:28]=[CH:27][C:26]([NH:29][C:30]([NH:32][C:33]2[CH:38]=[CH:37][CH:36]=[CH:35][CH:34]=2)=[O:31])=[CH:25][CH:24]=1>N1C=CC=CC=1.C(OC(=O)C)(=O)C>[C:3]([NH:8][CH2:9][C:10]1[CH:11]=[C:12]2[C:17](=[CH:18][C:19]=1[O:20][CH3:21])[N:16]=[CH:15][CH:14]=[C:13]2[O:22][C:23]1[CH:24]=[CH:25][C:26]([NH:29][C:30]([NH:32][C:33]2[CH:34]=[CH:35][CH:36]=[CH:37][CH:38]=2)=[O:31])=[CH:27][CH:28]=1)(=[O:4])[CH3:2]

Participants

4

Reactant 1

HCID 22936266HCID 22936266, compound

Product 1

HCID 22936256HCID 22936256, compoundYield 37.6%

Reagents, catalysts & solvents 2

HCID 1049PyridineSolventHCID 7918Acetic AnhydrideSolvent

Procedure

After dissolving N-[4-(6-aminomethyl-7-methoxy-quinolin-4-yloxy)phenyl]-N′-phenylurea trifluoroacetate (40 mg) in pyridine (1.0 ml) and acetic anhydride (1.0 ml), the solution was stirred overnight at room temperature. The reaction solution was concentrated under reduced pressure and the obtained crude product was crystallized with ethyl acetate to obtain the title compound (13 mg).

Workup

  1. concentrationThe reaction solution was concentrated under reduced pressure
  2. customthe obtained crude product
  3. customwas crystallized with ethyl acetate

Sources & evidence

ORD record
ord-b1d7857e10074d628b9a132a6766357f
Source dataset
uspto-grants-2007_08
Patent number
US07253286B2

Reaction notes

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