Dimethyl Sulfoxide → HCID 11682986, compound

HRID 853469Notes

Reaction equation

HRID 853469 reaction equation
[CH:1]1([NH2:4])[CH2:3][CH2:2]1.CS(C)=O.C1([O:15][C:16](=O)[NH:17][C:18]2[CH:23]=[CH:22][C:21]([O:24][C:25]3[C:34]4[C:29](=[CH:30][C:31]([O:38][CH3:39])=[C:32]([C:35](=[O:37])[NH2:36])[CH:33]=4)[N:28]=[CH:27][CH:26]=3)=[CH:20][C:19]=2[F:40])C=CC=CC=1.O>C(OCC)(=O)C>[F:40][C:19]1[CH:20]=[C:21]([O:24][C:25]2[C:34]3[C:29](=[CH:30][C:31]([O:38][CH3:39])=[C:32]([C:35](=[O:37])[NH2:36])[CH:33]=3)[N:28]=[CH:27][CH:26]=2)[CH:22]=[CH:23][C:18]=1[NH:17][C:16]([NH:4][CH:1]1[CH2:3][CH2:2]1)=[O:15]

Participants

6

Reactant 4

HCID 679Dimethyl SulfoxideHCID 962WaterHCID 69828CyclopropylamineHCID 22936982HCID 22936982, compound

Product 1

HCID 11682986HCID 11682986, compound

Reagents, catalysts & solvents 1

HCID 8857Ethyl AcetateSolvent

Procedure

Cyclopropylamine (0.10 ml) was added to dimethylsulfoxide (0.8 ml), and then [4-(6-carbamoyl-7-methoxyquinolin-4-yloxy)-2-fluorophenyl]carbamic acid phenyl ester (80 mg) was dissolved therein and the mixture was stirred for 10 minutes. Water and ethyl acetate were added to the reaction solution and the precipitated crystals were filtered out to obtain the title compound (33 mg).

Workup

  1. filtrationthe precipitated crystals were filtered out

Sources & evidence

ORD record
ord-909f25baa79c403d9c1083d0c384aef0
Source dataset
uspto-grants-2007_08
Patent number
US07253286B2

Reaction notes

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