Dimethylamine → HCID 67305981, compound

HRID 853481Notes

Reaction equation

HRID 853481 reaction equation
[CH3:1][NH:2][CH3:3].[C:4]([C:6]1[CH:7]=[C:8]2[C:13](=[CH:14][C:15]=1[O:16][CH2:17][C@H:18]1[CH2:20][O:19]1)[N:12]=[CH:11][CH:10]=[C:9]2[O:21][C:22]1[CH:27]=[CH:26][C:25]([NH:28][C:29]([NH:31][C:32]2[CH:37]=[CH:36][C:35]([F:38])=[CH:34][CH:33]=2)=[O:30])=[C:24]([F:39])[CH:23]=1)#[N:5]>O1CCCC1>[C:4]([C:6]1[CH:7]=[C:8]2[C:13](=[CH:14][C:15]=1[O:16][CH2:17][C@H:18]([OH:19])[CH2:20][N:2]([CH3:3])[CH3:1])[N:12]=[CH:11][CH:10]=[C:9]2[O:21][C:22]1[CH:27]=[CH:26][C:25]([NH:28][C:29]([NH:31][C:32]2[CH:33]=[CH:34][C:35]([F:38])=[CH:36][CH:37]=2)=[O:30])=[C:24]([F:39])[CH:23]=1)#[N:5]

Participants

4

Reactant 2

HCID 674DimethylamineHCID 86591472HCID 86591472, compound

Product 1

HCID 67305981HCID 67305981, compound

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

After adding tetrahydrofuran (0.5 ml) and a dimethylamine-2N tetrahydrofuran solution (Aldrich, 0.2 ml) to N-(4-{6-cyano-7-[(2R)-oxiran-2-yl]methoxyquinolin-4-yloxy}-2-fluorophenyl)-N′-(4-fluorophenyl)urea (40 mg), the mixture was stirred overnight at room temperature. The reaction solution was purified by NH silica gel column chromatography (ethyl acetate-methanol system) to obtain the title compound (45 mg) as light yellow crystals.

Workup

  1. customThe reaction solution was purified by NH silica gel column chromatography (ethyl acetate-methanol system)

Sources & evidence

ORD record
ord-4b83a5707fc942dc98b5922600347be5
Source dataset
uspto-grants-2007_08
Patent number
US07253286B2

Reaction notes

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