Toluene → HCID 58931434, compound

HRID 853498Notes

Reaction equation

HRID 853498 reaction equation
C1(C)C=CC=CC=1.[F:8][C:9]1[CH:14]=[CH:13][C:12]([N:15]=[C:16]=[O:17])=[CH:11][CH:10]=1.[C:18]1([C:24]2[O:40][C:27]3[N:28]=[CH:29][N:30]=[C:31]([O:32][C:33]4[CH:38]=[CH:37][C:36]([NH2:39])=[CH:35][CH:34]=4)[C:26]=3[CH:25]=2)[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=1>C(#N)C>[F:8][C:9]1[CH:14]=[CH:13][C:12]([NH:15][C:16]([NH:39][C:36]2[CH:35]=[CH:34][C:33]([O:32][C:31]3[C:26]4[CH:25]=[C:24]([C:18]5[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=5)[O:40][C:27]=4[N:28]=[CH:29][N:30]=3)=[CH:38][CH:37]=2)=[O:17])=[CH:11][CH:10]=1

Participants

5

Reactant 3

HCID 1140TolueneHCID 709554-Fluorophenyl isocyanateHCID 58931477HCID 58931477, compound

Product 1

HCID 58931434HCID 58931434, compound

Reagents, catalysts & solvents 1

HCID 6342AcetonitrileSolvent

Procedure

After adding toluene (1 ml), acetonitrile (0.5 ml) and 4-fluorophenyl isocyanate (0.03 ml) to 4-(6-phenyl-furo[2.3-d]pyrimidin-4-yloxy)phenylamine (40 mg), the mixture was heated to reflux for 30 minutes. After cooling, the precipitated crystals were filtered out and washed with toluene to obtain the title compound (42 mg) as light yellow crystals.

Workup

  1. temperaturethe mixture was heated
  2. temperatureto reflux for 30 minutes
  3. temperatureAfter cooling
  4. filtrationthe precipitated crystals were filtered out
  5. washwashed with toluene

Sources & evidence

ORD record
ord-34d9583d4c6c428b8605562fb1d83982
Source dataset
uspto-grants-2007_08
Patent number
US07253286B2

Reaction notes

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