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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 853498Generated: October 30, 2026

Toluene → HCID 58931434, compound

https://huagongshe.com/reaction/853498

Reaction equation

Participants

RoleNameHCIDCharge
ReactantTolueneHCID 1140—
Reactant4-Fluorophenyl isocyanateHCID 70955—
ReactantHCID 58931477HCID 58931477—
SolventAcetonitrileHCID 6342—
ProductHCID 58931434HCID 58931434—

Reaction Steps

After adding toluene (1 ml), acetonitrile (0.5 ml) and 4-fluorophenyl isocyanate (0.03 ml) to 4-(6-phenyl-furo[2.3-d]pyrimidin-4-yloxy)phenylamine (40 mg), the mixture was heated to reflux for 30 minutes. After cooling, the precipitated crystals were filtered out and washed with toluene to obtain the title compound (42 mg) as light yellow crystals.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS07253286B2
Source datasetuspto-grants-2007_08
ORD IDord-34d9583d4c6c428b8605562fb1d83982
Source noteuspto-grants-2007_08